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What are the steps in LD50/LC50 testing?
Animal testing, dose/concentration exposure, observation, and calculation.
What are the general steps of an LD50 test?
Animal testing, dose/concentration exposure, observation, calculation.
What does a low LD50 value indicate?
The substance is highly toxic.
Why are LD50s studied?
To compare toxicity, assess risk, guide regulations, and identify hazards.
What factors should be considered when comparing LD50 values?
Species, route of exposure, and test conditions.
What is the main use of LD50 values?
Determining acute toxicity of a substance.
What is a limitation of LD50 values?
They don't predict long-term effects or effects of chemical mixtures.
How does LD50 data help occupational health and safety?
It helps set safe exposure limits for workers and guides protective measures.
How is LD50/LC50 calculated?
Based on the dose/concentration that kills 50% of the test animals.
What is the significance of J.W. Trevan?
He introduced the concept of LD50 in 1927, marking a crucial step in toxicology.
What is the importance of knowing the route of exposure?
The route of exposure is the most important LD50 info (oral, dermal) and the LD50 value itself.
How is animal LD50 data applied to humans?
Animal LD50 data provides a general idea of a chemical's toxicity in humans, but direct application is not possible.